C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 45/08 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/18 (2006.01) C12N 9/20 (2006.01) C12N 15/52 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01) C12Q 1/44 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2273823
Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
L'invention concerne des polypeptides du type lipoprotéine lipase, des acides nucléiques codant de tels polypeptides, des séquences antisens ainsi que des anticorps dirigés contre de tels polypeptides. L'invention concerne également des procédés de préparation de ces polypeptides, dans un système de recombinaison, ainsi que l'utilisation de ceux-ci pour cribler des agonistes et/ou antagonistes de ces polypeptides. L'invention concerne enfin des procédés et compositions de traitement des troubles du métabolisme lipidique.
Amin Dilip V.
Doan Kim-Anh Thi
Jaye Michael C.
Krawiec John A.
Lynch Kevin J.
Aventis Pharmaceuticals Inc.
Goudreau Gage Dubuc
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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