C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/31 (2006.01) A61K 39/085 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2744054
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides and compositions thereof SEQ ID NO: 1 is a full length S. aureus sequence. A derivative of SEQ ID NO: 1 containing an amino terminus his-tag was found to produce a protective immune response against S. aureus.
La présente invention concerne des polypeptides comprenant une séquence dacides aminés structuralement apparentés à SEQ ID NO: 1 et des utilisations de tels polypeptides et des compositions de ceux-ci. SEQ ID NO: 1 est une séquence de S. aureus de longueur totale. Il a été découvert quun dérivé de SEQ ID NO: 1 contenant une étiquette his amino-terminale induit une réponse immunitaire protectrice contre S. aureus.
Cope Leslie D.
Mcneely Tessie B.
Miller Mark A.
Schultz Loren D.
Wang Xinmin
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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