Polysaccharidic esters of n-derivatives of glutamic acid

Details Polysaccharidic esters of n-derivatives of glutamic acid Polysaccharidic esters of n-derivatives of glutamic acid

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/715 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2403063

The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.

La présente invention concerne des esters polysaccharidiques de dérivés N- de l'acide glutamique (dérivés N-AG). Ces esters polysaccharidiques ont une activité antiproliférative et sont caractérisés par une faible toxicité systémique. Les esters de l'invention sont utilisés dans la prévention et la thérapie de maladies causées par l'hyperprolifération cellulaire, en particulier le psoriasis, les tumeurs, l'arthrite rhumatoïde, ou les pathologies inflammatoires intestinales.

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