C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 7/08 (2006.01) C12N 15/40 (2006.01) C07K 14/08 (2006.01)
Patent
CA 2370372
Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation.
L'invention porte sur des formes quasiment non virulentes du virus porcin atypique du SDRP (syndrome dysgénésique respiratoire porcin) et sur les vaccins correspondants obtenus par passage en culture de cellules des formes virulentes du SDRP. Le virus atypique non virulent du SDRP peut servir de vaccin car il suscite dans l'animal inoculé une réponse d'anticorps spécifiques lui conférant une immunité efficace et contre les souches précédemment connues du virus SDRP, et contre les souches nouvellement isolées du virus SDRP atypique. La technique de passage en culture préférée permet de maintenir le virus en phase de croissance logarithmique pendant presque tout le processus, ce qui réduit le temps nécessaire à l'atténuation.
Burkhart Kelly
Gorcyca David E.
Lager Kelly
Mengeling William L.
Roof Mike
Boehringer Ingelheim Vetmedica Inc.
Gowling Lafleur Henderson Llp
United States Department Of Agriculture
United States Of America As Represented By The Secretary Of Agriculture
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