C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A01N 43/90 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2247020
The present invention relates to novel optionally substituted 8-cyano-1-cyclo- propyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo- 3-quinolinecarboxylic acids and their derivatives, of the general formula (I) (see formula I) in which R1 represents hydrogen, C1-C4-alkyl which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl- 2-oxo-1,3-dioxol-4-yl)methyl, R2 represents hydrogen, benzyl, C1-C3-alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)- methyl, radicals having the structures -CH=CH-COOR3, -CH2CH2COOR3, -CH2CH2CN, -CH2CH2COCH3 or -CH2COCH3, in which R3 represents methyl or ethyl, or a radical of the general structure R4-(NH-CHR5-CO)n-, in which R4 represents hydrogen, C1-C3-alkyl or the radical -COO-tert-butyl, R5 represents hydrogen, C1-C4-alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, carboxyalkyl or benzyl and n is 1 or 2, and Y is oxygen or sulfur, the process for their preparation and their use in antibacterial compositions.
L'invention concerne de nouveaux acides 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-(4.3.0)-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinocarboxyliques éventuellement substitués et leurs dérivés, de formule générale (I), dans laquelle R<1> représente hydrogène, alkyle C1-C4 éventuellement substitué par hydroxy, méthoxy, amino, méthylamino ou diméthylamino, ou représente (5-méthyl-2-oxo-1,3-dioxol-4-yl)-méthyle; R<2> représente hydrogène, benzyle, alkyle C1-C3, (5-méthyl-2-oxo-1,3-dioxol-4-yl)-méthyle, des radicaux de structures -CH=CH-COOR<3>, -CH2CH2COOR<3>, -CH2CH2CN, -CH2CH2COCH3, -CH2COCH3 (dans lesquelles R<3> représente méthyle ou éthyle) ou un radical de structure générale R<4>-(NH-CHR<5>-CO)n- (dans laquelle R<4> représente hydrogène, alkyle C1-C3 ou le radical -COO-tert.-butyle, R<5> représente hydrogène, alkyle C1-C4, hydroxyalkyle, aminoalkyle, thioalkyle, carboxyalkyle ou benzyle et n vaut 1 ou 2); et Y représente oxygène ou soufre. L'invention concerne également le procédé de production desdits composés et leur utilisation en tant qu'agent antibactérien.
Bartel Stefan
Hallenbach Werner
Heinen Ernst
Himmler Thomas
Jaetsch Thomas
Aktiengesellschaft Bayer
Bayer Animal Health Gmbh
Fetherstonhaugh & Co.
LandOfFree
Possibly substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Possibly substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Possibly substituted... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1974463