Pradimicin derivatives

Details Pradimicin derivatives Pradimicin derivatives

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01)

Patent

CA 2162186

Disclosed are neutral sugar derivatives of pradimicins (BU-3608 antibiotics), their use as antifungal agents, methods for their preparation and intermediates for their synthesis. Said derivatives include a compound having the formula Image wherein R1 is selected from the group consisting of H and hydroxymethyl, and when R1 is hydroxymethyl, the resulting amino acid residue has the D-configuration; and R2 is H or .beta.-D-xylosyl or a pharmaceutically acceptable salt thereof.

Divulgation de dérivés de sucres neutres des pradimicines (antibiotiques BU-3608), de leur utilisation comme agents antifongiques, de méthodes pour les préparer et d'intermédiaires pour leur synthèse. Ces dérivés comprennent un composé ayant la formule Image , dans laquelle R1 est choisi dans le groupe constitué de H et d'hydroxyméthyle, et quand R1 est un hydroxyméthyle, le résidu d'acide aminé résultant a la configuration D; et R2 est H ou un .bêta.-D-xylosyle ou un sel correspondant utilisable en pharmacie.

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