A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/74 (2006.01)
Patent
CA 2483696
A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors over-expressed on cancer cell surface. Compounds composed of a carrier molecule, wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid, are described. Also described are methods comprising pre-administering a non-HA GAG blocking agent before administering the HA conjugate. Also described are methods of making and using the compounds thereof.
L'invention concerne un système d'administration de médicaments polymériques sur des cellules ciblées, basé sur l'interaction spécifique entre l'acide hyaluronique (HA) et ses récepteurs de surface cellulaire surexprimés sur la surface de la cellule cancéreuse. L'invention concerne également des composés d'une molécule de transport, ladite molécule de transport contenant au moins un reste d'un agent anticancéreux et au moins un reste d'acide hyaluronique. L'invention concerne en outre des méthodes consistant à administrer de façon préalable un agent de blocage GAG non HA avant d'administrer le conjugué HA. L'invention concerne enfin des méthodes de fabrication et d'utilisation de ces composés.
Prestwich Glenn D.
Zhang Lurong
Georgetown University
Prestwich Glenn D.
Ridout & Maybee Llp
University Of Utah
University Of Utah Research Foundation
LandOfFree
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