Precipitation of proteins from salt-containing proteinaceous...

A - Human Necessities – 23 – J

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A23J 1/00 (2006.01) A23C 9/144 (2006.01) A23J 1/06 (2006.01) A23J 1/20 (2006.01) A61M 1/34 (2006.01) C07K 1/30 (2006.01) C07K 14/76 (2006.01) C07K 16/06 (2006.01)

Patent

CA 1210759

PRECIPITATION OF PROTEINS FROM SALT-CONTAINING PROTEINACEOUS FLUIDS EMPLOYING A DESALTING TREATMENT, AND USE THEREOF IN SELECTIVE PLASMAPHERESIS ABSTRACT OF THE DISCLOSURE Total or fractional precipitation of proteins from salt-containing proteinaceous solution or sus- pension mixtures is induced or enhanced by subjecting the proteinaceous mixture to a desalting treatment, for example, by electrodialysis. In one aspect of the invention, the desalting treatment is used in conjunction with the addition of heavy metal ions to the proteinaceous mixture to provide a synergistic effect on the precipitation of the protein fraction. In another aspect of the invention, the desalting treatment, either with or without the heavy metal ion additon, is employed as an integral part of a selective plasmapheresis procedure for the removal or recovery of one or more selected plasma proteins from blood plasma.

396026

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