A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 5/00 (2006.01) A61B 5/145 (2006.01) G01N 33/48 (2006.01) G01N 33/483 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2755050
Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.
La présente invention concerne des procédés d'évaluation du risque de maladie cardiovasculaire chez un sujet par détection du niveau d'au moins un métabolite dans un échantillon du sujet. Le niveau du métabolite indique le risque de maladie cardiovasculaire chez le sujet. Les métabolites peuvent être des acylcarnitines, des acides aminés, des cétones, des acides gras libres ou l'hydroxybutyrate. La maladie cardiovasculaire peut être un risque d'événement cardiovasculaire, la présence d'une maladie coronarienne ou un risque de développement d'une maladie coronarienne.
Ginsburg Geoffrey S.
Hauser Elizabeth R.
Kraus William E.
Newby L. Kristin
Newgard Christopher B.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Duke University
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