Preparation method of rosuvastatin calcium and its...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/42 (2006.01)

Patent

CA 2725052

A preparation method of rosuvastatin calcium (Formula 1), which can be used for the production of medicament lowering the levels of LDL-cholesterol and triglycerides in vivo, is provided. Such preparation method is suitable for industrial production. Furthermore, the intermediate crystallines used in the preparation method are provided. (see formula 1)

La présente invention concerne un procédé de préparation de la rosuvastatine calcique (formule 1), qui peut être utilisée pour la production d'un médicament diminuant les niveaux du LDL-cholestérol et des triglycérides in vivo. Un tel procédé de préparation est approprié pour une production industrielle. De plus, l'invention concerne les intermédiaires cristallins utilisés dans le procédé de préparation.

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