Preparation of 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine...

Details Preparation of 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine... Preparation of 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine...

C - Chemistry, Metallurgy

07

D

260/273

C07D 487/04 (2006.01) C07D 213/74 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1044238

A B S T R A C T New 1,6-naphthyridine derivatives of the formula (I) Image (I) useful as intermediates in preparing antibacterial agents. In the compounds R3 is hydrogen or C1-6 alkyl; Y is a tertiary nitrogen-containing aromatic, heterocyclic ring attached through the nitrogen atom, or a trialkyl-amino group and Z is an anion. The process is selected from a) Reacting a compound of the formula (III) Image (III) wherein the N-alkyl-group has 1-6 carbon atoms) with an aromatic tertiary base, or a trialkylamine, in the presence of a halogen, b) Reacting a compound of the formula (II) Image (II) wherein alkyl is as stated above, and X stands for halogen with a tertiary base; and c) Reacting the compound of the formula (IV) Image (IV) in the presence of a halogen with an aromatic tertiary base, or a trialkylamine, and, if desired, alkylating the compound of the formula (I) thus obtained (wherein R3 is hydrogen). If desired, the halide thus obtained may be converted into an other halide or an other pharmaceutically acceptable anion.

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