Preparation of beta-methyl carbapenem intermediates

Details Preparation of beta-methyl carbapenem intermediates Preparation of beta-methyl carbapenem intermediates

C - Chemistry, Metallurgy

07

D

C07D 205/08 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 409/06 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2106248

TITLE OF THE INVENTION PREPARATION OF BETA-METHYL CARBAPENEM INTERMEDIATES ABSTRACT OF THE INVENTION The present invention is directed to a process of making a Beta-methyl carbapenem intermediate of formula VI from a compound of formula I Image Image I VI wherein R and P' are protecting groups R1 is a methylmalonic acid ester and Nu is a nucleophilic group. Process intermediates are also disclosed.

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