Preparation of enamines in aqueous media

C - Chemistry – Metallurgy – 07 – C

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C07C 255/58 (2006.01) C07C 227/18 (2006.01) C07C 229/54 (2006.01) C07C 253/30 (2006.01) C07D 219/10 (2006.01) C07D 221/16 (2006.01)

Patent

CA 2101568

Abstract A process for the preparation of enamines in aqueous media The present invention relates to a process for the preparation of enamines of the formula 1 Image wherein R is CN, CO2H, or CO2R1 wherein R1 is loweralkyl; Y is CH2 or C= O ; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, NHCOR2 wherein R2 is loweralkyl, or a group of the formula NR3R4 wherein R3 and R4 are independently hydrogen or loweralkyl; and n is 0, 1, or 2, which comprises condensing an aniline of formula 2 Image wherein R and X are as hereinbeforedefined with a cycloalkanone or -dione 3 Image wherein Y and n are as hereinbeforedefined in an aqueous medium containing an acidic promoter.

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