C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/52 (2006.01) C07C 39/06 (2006.01) C07C 211/63 (2006.01) C07C 215/48 (2006.01) C07C 215/74 (2006.01)
Patent
CA 2209688
Disclosed is a process for producing a compound of the formula (III), by adding a base of the formula (IV) to a solution of a compound of the formula (II) and a halonitromethane of the formula O2NCH2X (where X is halogen) dissolved in a non-aqueous inert solvent. The compound (III) is useful as an intermediate for the synthesis of antibiotic azabicyclo quinoline carboxylic acids (see fig.I) (see fig.II) (see fig.III) (wherein R1 and R3 are each hydrogen, alkyl or aryl or two of R1 form a ring, O is 0-5, m is 0-2, p is 0-3, R2 is alkyl or benzyl and R4 is alkyl).
Préparation d'un composé de formule (III), par addition d'une base de formule (IV) à une solution d'un composé de formule (II), et d'un halonitro-méthane de formule O2NCH2X (où X est un halogène), dissous dans un solvant inerte non aqueux. Le composé (III) est un intermédiaire pour la synthèse d'acides azabicyclo- quinoléinecarboxyliques antibiotiques (voir fig. I) (voir fig. II) (voir fig. III) (où R1 et R3 sont chacun de l'hydrogène, un alkyle ou un aryle, ou deux R1 forment un cycle, O est 0-5, m est 0-2, p est 0-3, R2 est un alkyle ou un benzyle et R4 un alkyle).
Limited Pfizer
Smart & Biggar
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