Preparation of nucleosides ribofuranosyl pyrimidines

Details Preparation of nucleosides ribofuranosyl pyrimidines Preparation of nucleosides ribofuranosyl pyrimidines

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) C07H 5/02 (2006.01)

Patent

CA 2666098

The present process provides an improved method for the preparation of 4- amino-l-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl- tetrahydro-furan-2-yl)-lH-pyrimidin-2-one of the formula (IV) which is a potent inhibitor of Hepatitis C Virus (HCV) NS5B polymerase.

La présente invention concerne un procédé amélioré de préparation de 4-amino-l-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxyméthyl-3-méthyltétrahydrofuran-2-yl)-lH-pyrimidin-2-one répondant à la formule (IV), ce composé étant un puissant inhibiteur de la polymérase NS5B du virus de l'hépatite C (VHC).

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