A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 31/167 (2006.01) A61K 31/192 (2006.01) A61K 31/60 (2006.01)
Patent
CA 2657586
A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the opioid in the carrier.
L'invention concerne un procédé de production d'une composition comprenant un opioïde insoluble dans l'eau, consistant a) à former un mélange contenant i) un opioïde insoluble dans l'eau, ii) un excipient soluble dans l'eau et iii) un solvant pour l'opioïde et un autre pour l'excipient, et b) à sécher par pulvérisation le mélange pour éliminer le solvant ou chaque solvant et obtenir dans l'excipient une nano-dispersion de l'opioïde sensiblement exempte de solvant.
Chauvin Daniele
Duncalf David John
Elphick Andrew James
Foster Alison Jayne
Long James
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Plc Unilever
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