Presenilin enhancers

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408166

The invention provides methods and compositions relating to pen polypeptides having pen-specific structure and activity, related polynucleotides and modulators of pen function. The invention provides isolated pen hybridization probes and primers capable of specifically hybridizing with natural pen genes, pen-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis (e.g. genetic hybridization screens for pen transcripts), therapy (e.g. pen inhibitors to modulate APP processing) and in the biopharmaceutical industry (e.g. as immunogens, reagents for screening chemical libraries for lead pharmacological agents, etc.).

L'invention concerne des procédés et des compositions se rapportant à des polypeptides d'amplificateurs de préséniline, pen, ayant une structure et activité pen propres, ainsi que des polynucléotides et modulateurs connexes de la fonction pen. L'invention concerne des sondes et des amorces d'hybridation isolées de pen capables de s'hybrider spécifiquement aux gènes naturels de pen, sur des agents de liaison spécifiques des pen, tels que des anticorps. Elle concerne également des procédés de fabrication et d'utilisation de ces compositions dans les diagnostics (cribles génétiques d'hybridation pour des produits de transcription de pen), en thérapie (par exemple des inhibiteurs de pen pour moduler le traitement APP), et dans l'industrie biopharmaceutique (par exemple comme immunogènes, comme réactifs pour cribler les bibliothèques chimiques d'agents pharmacologiques à base de plomb, etc.).

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