Preventive or remedy for arteriosclerosis comprising...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2493859

A scavenger receptor A expression regulating agent and a preventive/remedy for arteriosclerosis which comprise, as the active ingredient, a spherical region in the C-terminal side of adiponectin, adiponectin or a gene thereof. Thus, it is possible to provide a preventive/remedy for arteriosclerosis which regulates the expression of scavenger receptor A of the arterial wall, thus inhibits the accumulation of lipids in microphages and prevents the onset and progress of arteriosclerosis to thereby directly prevent endangium from thickening (i.e., the entity of arteriosclerosis).

L'invention concerne un agent régulateur de l'expression du récepteur SR-A (scavenger receptor de type A) et un médicament préventif/curatif pour l'artériosclérose qui contient en tant que principe actif, une région sphérique de la partie C-terminale de l'adiponectine, de l'adiponectine ou un gène de celle-ci. Cet agent permet la préparation d'un médicament préventif/curatif pour l'artériosclérose, qui régule l'expression du récepteur SR-A de la paroi artérielle, et inhibe ainsi l'accumulation de lipides dans les microphages et prévient l'apparition et la progression de l'artériosclérose, en empêchant directement l'épaississement de la tunique interne des artères (soit l'entité sujette à l'artériosclérose).

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