Prion epitopes and methods of use thereof

Details Prion epitopes and methods of use thereof Prion epitopes and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2721833

Prion peptides comprising prion epitopes having the amino acid sequence VYYRP, and repeats and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease using the peptides, encoding polynucleotides or antibodies thereof.

La présente invention concerne des peptides de prion comportant des épitopes de prion et des fusions de ceux-ci présentant une immunogénicité améliorée. Linvention concerne également des procédés de traitement et de diagnostic de maladies à prions.

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