Process

Details Process Process

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2290830

A process producing a pharmaceutical lozenge formulation comprising the steps of: 1) granulating a mixture of flurbiprofen and a bulking agent with a solution of a binding agent in a polar solvent to form granules; 2) melting a lozenge-forming composition; 3) mixing the granules with the molten lozenge-forming composition; 4) forcing the resulting mixture into lozenges each containing a therapeutically effective amount of flurbiprofen.

L'invention concerne un procédé de production d'une formulation de pastilles de flurbiprofène, le procédé consistant: 1- à transformer en granules un mélange de flurbiprofène et de diluant avec une solution d'agent de liaison dans un solvant polaire pour former des granulés; 2- à fondre une composition de formation de pastilles; 3- à mélanger les granulés avec la composition de formation de pastilles fondue; 4- à former le mélange obtenu en pastilles contenant chacune une dose de flurbiprofène efficace sur le plan thérapeutique.

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