C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/62 (2006.01) C07K 1/14 (2006.01)
Patent
CA 2110442
Process for obtaining proinsulin possessing correctly licked cystine bridges A process is described for obtaining proinsulin possessing correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan and chaotropic auxiliary agents and at a pH of 10 to 11, as well as its direct isolation from the reaction mixture using hydrophobic adsorber resins.
Gerl Martin
Ludwig Jurgen
Obermeier Rainer
Sabel Walter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
Sanofi-Aventis Deutschland Gmbh
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