Process for preparation of endothelial receptor antagonist...

Details Process for preparation of endothelial receptor antagonist... Process for preparation of endothelial receptor antagonist...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/513 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2758108

The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2- methoxyphenoxy)-2-(2-pyrimidinyl)-4--pyrimidinyl] benzene sulfonamide (bosentan).

La présente invention concerne des procédés de préparation d'un antagoniste du récepteur endothélial. La présente invention concerne en particulier la synthèse de 4-tert-butyl-n-[ 6-(2-hydroxyéthoxy)-5-(2-méthoxyphénoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl ] benzène sulfonamide (bosentan).

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