C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01)
Patent
CA 2645189
The invention relates to a polymorphic form of 5-(4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione (Formula (I)): to a process for its preparation and to the use of such compound for preparing rosiglitazone in the form of a free base or a salt thereof. The invention also relates to a polymorphic form of rosiglitazone in the form of a free base, to a process for its preparation and to the use of such polymorph for preparing a salt of rosiglitazone. The invention also relates to a process of preparing a polymorphic form of a rosiglitazone salt.
L'invention concerne une forme polymorphe de 5-(4-[2-(N-méthyl-N-(2- pyridyl)amino)éthoxy]benzylidène)-2,4-thiazolidinedione, un procédé pour la préparer et l'utilisation de ce composé pour préparer de la rosiglitazone sous forme de base libre ou de sel de celle-ci. L'invention porte également sur une forme polymorphe de la rosiglitazone sous forme de base libre, sur un procédé pour la préparer et sur l'utilisation de cette forme polymorphe pour préparer un sel de rosiglitazone. L'invention concerne aussi un procédé de préparation d'une forme polymorphe d'un sel de rosiglitazone.
Gowling Lafleur Henderson Llp
Medichem S.a.
LandOfFree
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