Process for preparing 1.alpha.-hydroxylated compounds

C - Chemistry – Metallurgy – 07 – C

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260/474, 260/646

C07C 172/00 (1985.01)

Patent

CA 1254225

ABSTRACT Novel cyclovitamin compounds of the formula Image wherein X is hydrogen, hydroxy, O-acyl or O-aromatic acyl, Z is hydrogen, lower alkyl, acyl or aromatic acyl and R is hydrogen or lower alkyl or a side chain of the general for- mula Image are prepared from the corresponding compounds of the formula Image via the C-3-sulfonic acid ester and then solvolyzing the ester in an alcoholic or aqueous solvent. The compounds are useful as intermediates in the preparation of the corres- ponding l.alpha.-hydroxylated vitamin D compounds which have vitamin D-like activity.

425450

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