Process for preparing crystalline form i of cabergoline

Details Process for preparing crystalline form i of cabergoline Process for preparing crystalline form i of cabergoline

C - Chemistry, Metallurgy

07

D

C07D 457/06 (2006.01) A61K 31/42 (2006.01) C07D 261/08 (2006.01)

Patent

CA 2479140

A process for producing crystalline form I of cabergoline, which process comprises the preparation of Form V using heptane as precipitation solvent, and its exclusive conversion into crystalline Form I of cabergoline. The present crystallization process from toluene-heptane solvent system for form V involves "reverse addition" of toluene-cabergoline concentrate to cold heptane.

L'invention a trait à un procédé de production de la forme cristalline I de la cabergoline, consistant à préparer la forme V en utilisant l'heptane comme solvant de précipitation, et à la transformer de manière exclusive en la forme cristalline I de la cabergoline. Le présent procédé de cristallisation, qui part d'un système de solvant toluène-heptane pour obtenir la forme V, comprend l'étape d'<=ajout inversé >= d'un concentré de toluène-cabergoline àl'heptane froid.

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