Process for preparing dorzolamide

Details Process for preparing dorzolamide Process for preparing dorzolamide

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01)

Patent

CA 2646133

A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S) - (+) -10-camphorsulfonic acid so obtaining the (4S, 6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate) , and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.

La présente invention a pour objet un procédé de dédoublement du racémate trans du dorzolamide qui comprend la réaction dudit racémate avec l'acide (1S)-(+)-10-camphorsulfonique pour obtenir l'énantiomère (4S,6S) par précipitation sélective et récupération de son sel avec l'acide camphorsulfonique (camphorsulfonate de dorzolamide), et la neutralisation du camphorsulfonate de dorzolamide pour obtenir le dorzolamide.

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