Process for preparing l(-)-carnitine chloride

Details Process for preparing l(-)-carnitine chloride Process for preparing l(-)-carnitine chloride

C - Chemistry, Metallurgy

12

P

195/134.2

C12P 13/04 (2006.01) C12P 17/02 (2006.01) C12P 41/00 (2006.01)

Patent

CA 1309048

ABSTRACT OF THE DISCLOSURE A biotechnological process for preparing L(-)-carnitine chloride, having the formula (I): Image (I) comprising: (a) reacting a racemic ester of (R,S)-3,4- epoxy-butyric acid having the formula (II): Image (II) wherein R is an alkyl group having from 1 to 10 carbons or a benzyl group, with an enzyme capable of selectively hydrolyzing enantiomer S(-); (b) separating the enantiomer S(-) from non-reacted ester which is present in predominantly the R(+) form; (c) reacting the non- reacted ester obtained in step (b) with an enzyme capable of quantitavely hydrolyzing the R(+) form to obtain thereby a salt of 3,4-epoxybutyric acid in the R(+) form having the formula (III): Image (III) wherein X is Na, K, or Li; (d) reacting the salt obtained in step (c) with a molar excess of trimethyla- mine; and (e) treating the reaction product of step (d) with HCl to remove excess trimethylamine and to obtain thereby the L(-)-carnitine chloride of formula (I). This process is simple, efficient and economical on an industrial scale.

532035

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