Process for preparing solid dosage forms of very low-dose drugs

Details Process for preparing solid dosage forms of very low-dose drugs Process for preparing solid dosage forms of very low-dose drugs

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/435 (2006.01) A61K 31/439 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2228048

A drug formulation process which comprises admixing carrier particles with a solution of drug in water in a quantity of 1-3 % by weight of solution to total mix and a method of treatment and/or prophylaxis of dementia, which method comprises administering to the patient [R-(Z)]-.alpha.-(methoxyimino)- .alpha.-(1-azabicyclo [2.2.2]oct-3-yl)acetonitrile monohydrochloride at a daily dose below 0.01 mg/kg and pharmaceutical compositions used therein.

Cette invention concerne un procédé de formulation d'un médicament qui consiste à mélanger des particules d'excipient à une solution aqueuse contenant un médicament, ladite solution représentant de 1 à 3 % en poids du mélange total. L'invention concerne également un procédé de traitement et/ou de prophylaxie de la démence qui consiste à administrer à un patient du monochlorhydrate de [R-(Z)]-.alpha.-(méthoxyimino)-.alpha.-(1-azabicyclo[2.2.2]oct-3-yl)acétonitrile en une dose quotidienne ne dépassant pas 0,01mg/kg, ainsi que les compositions pharmaceutiques utilisées dans ce type de traitement.

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