C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/16 (2006.01) C07C 277/00 (2006.01) C07D 261/20 (2006.01)
Patent
CA 2377240
The invention relates to a process for preparing substituted cyclopentane derivatives represented by formula (I) wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to a process for purifying the compound of formula (Ia) and novel crystalline forms of the compound of formula (Ia).
L'invention concerne un procédé de préparation de dérivés de cyclopentane substitués représentés par la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, X et Y sont tels que définis dans la description. L'invention concerne également les sels pharmaceutiquement acceptables de ces dérivés. Cette invention concerne en outre un procédé de purification d'un composé de formule (Ia), ainsi que de nouvelles formes cristallines de ce composé de formule (Ia).
Abdel-Magid Ahmed F.
Bichsel Hans-Ulrich
Korey Daniel J.
Laufer Gunther G.
Lehto Erja A.
Biocryst Pharmaceuticals Inc.
Moffat & Co.
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