Process for producing a peptide

Details Process for producing a peptide Process for producing a peptide

C - Chemistry, Metallurgy

12

P

195/134

C12P 21/00 (2006.01) C07K 1/02 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01) C07K 5/093 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/113 (2006.01) C07K 7/06 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1059051

ABSTRACT OF THE DISCLOSURE A peptide having the formula: X-A-B-Y wherein A and B are the same or different and represent an amino acid residue or a peptide residue; X represents an amino protect- ive group and Y represents a carboxyl protective group, is prepared by reacting an amino acid or peptide having an N-terminal protective group or a salt thereof of the formula: X-A-OH with an amino acid or peptide having a C-terminal protective group or a salt thereof of the formula: H-B-Y in the presence of metalloproteinase in an aqueous solution having a pH which maintains the enzyme activity of said metallo- proteinase.

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