Process for producing block copolymer/drug composite

Details Process for producing block copolymer/drug composite Process for producing block copolymer/drug composite

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61K 9/127 (2006.01) A61K 31/704 (2006.01) A61K 47/34 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2490704

A process for producing a block copolymer/drug composite that can be industrialized, wherein neither dialysis nor ultrafiltration is performed and wherein halogenated hydrocarbons are not used. The process for producing a block copolymer/drug composite is characterized by comprising the steps of dissolving an AB type block copolymer composed of hydrophilic polymer structure moiety and hydrophobic polyamino aid structure moiety together with a drug in water or a mixed solvent of water and a low-boiling-point organic solvent miscible with water and concentrating the resultant solution.

L'invention porte sur un procédé de production d'un composite de copolymère séquencé/médicament pouvant être industrialisé et dans lequel aucune dialyse, ni ultrafiltration n'est effectuée, pas plus que ne sont utilisés des hydrocarbures halogénés. Le procédé de production d'un composite de copolymère séquencé/médicament se caractérise en ce qu'il consiste à dissoudre un copolymère séquencé de type AB composé d'une fraction de structure polymère hydrophile et d'une fraction de structure auxiliaire polyamino hydrophobe conjointement avec un médicament dans l'eau ou un solvant mixte renfermant de l'eau et un solvant organique à bas point d'ébullition miscible à l'eau et à concentrer la solution obtenue.

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