Process for producing ribofuranose derivatives

Details Process for producing ribofuranose derivatives Process for producing ribofuranose derivatives

C - Chemistry, Metallurgy

07

H

C07H 5/02 (2006.01) C07H 13/06 (2006.01) C07H 15/04 (2006.01) C07H 19/067 (2006.01)

Patent

CA 2707641

The invention aims to provide a process for producing 1,2,3-tri-O-acetyl-5- deoxyribofuranose by an industrially suitable means. The invention provides a process for the production of 1,2,3-tri-O-acetyl-5-deoxyribofuranse which comprises hydrogenating a compound represented by the general formula (1) or (2) in the presence of a metal catalyst: [wherein P1 and P2 are each independently hydrogen or acyl, or OP1 and OP2 may be united to form an acetal group; and R is hydrogen, alkyl, aryl, aralkyl or acyl] [wherein X1 is Br or I; P3 and P4 are each independently hydrogen or acyl; and R is hydrogen, alkyl, aryl, aralkyl or acyl].

L'invention concerne un procédé de production de 1,2,3-tri-O-acétyl-5-désoxyribofuranose par un moyen industriellement adapté. L'invention concerne un procédé de production de 1,2,3-tri-O-acétyl-5-désoxyribofuranose, consistant à hydrogéner un composé représenté par la formule générale (1) ou (2) en présence d'un catalyseur métallique: [dans laquelle P1 et P2 sont chaun indépendamment hydrogène ou acyle, ou OP1 et OP2 peuvent être assemblés pour former un groupe acétal; et R est hydrogène, alkyle, aryle, aralkyle ou acyle]; [dans laquelle X1 est Br ou I; P3 et P4 sont chacun indépendamment hydrogène ou acyle; et R est hydrogène, alkyle, aryle, aralkyle ou acyle].

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