Process for production of 4-(substituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 498/04 (2006.01) C07D 265/30 (2006.01)

Patent

CA 2710485

4-(Substituted phenyl)hexahydropyrido [2,1-c][1,4]oxazin- 6-one represented by formula (I) (see formula I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an A.beta. production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) (see formula II) or a salt thereof to an intramolecular condensation reaction.

L'invention porte sur une 4-(phényl-substituée)hexahydropyrido[2,1-c][1,4]oxazin-6-one représentée par la formule (I) ou sur un sel de cette dernière, utilisés comme intermédiaire dans la production d'un composé cinnamide bicyclique qui est un inhibiteur de la production d'Aß. On peut produire la 4-(phényl-substituée)hexahydropyrido[2,1-c][1,4]oxazin-6-one ou le sel de cette dernière de manière avantageuse pour l'industrie en soumettant un composé représenté par la formule (II) ou un sel de ce dernier à une réaction de condensation intramoléculaire.

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