Process for synthesizing carbapenem side chain intermediates

Details Process for synthesizing carbapenem side chain intermediates Process for synthesizing carbapenem side chain intermediates

C - Chemistry, Metallurgy

07

D

C07D 495/08 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 409/12 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2294342

A process of synthesizing a compound of formula (1) is described. A compound of formula (2) is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula (4). Compound (4) is then reacted with a group II metal sulfide source in water to produce a compound of formula (1).

L'invention concerne un procédé de synthétisation d'un composé de formule (1). Un composé de formule (2) est mis à réagir tout d'abord avec un chlorure diphénylphosphinique, afin d'activer le groupe acide carboxylique, puis avec un chlorure méthanesufonyle, afin de produire un composé de formule (4). Ce composé de formule (4) est ensuite mis à réagir avec une source de sulfure d'un métal de groupe II dans de l'eau, afin de produire un composé de formule (1).

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