Process for the crystallization from water of...

Details Process for the crystallization from water of... Process for the crystallization from water of...

C - Chemistry, Metallurgy

07

C

C07C 231/24 (2006.01) C07C 231/22 (2006.01)

Patent

CA 2204734

This invention refers to a process for the crystallization from water of S- N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy- 1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide known as Iopamidol. According to the process of this invention, a crystalline anhydrous Iopamidol in accordance with pharmacopeia standards can be obtained.

L'invention concerne un procédé de cristallisation, à partir d'eau, de S-N,N'-bis[2-hydroxy-1-(hydroxyméthyl)éthyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzènedicarboxamide, connu en tant qu'iopamidol. Selon le procédé de l'invention, on peut obtenir un iopamidol anhydre cristallin correspondant aux normes de la pharmacopée.

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