Process for the extraction of paclitaxel and...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 305/14 (2006.01)

Patent

CA 2536000

This invention provides a method to extract an organic solution of paclitaxel by way of purification technology which uses a "Load and Lock Axial Compression Column" for industrial scale preparative high performance liquid chromatography. The "Load and Lock Axial Compression Column" is one in which a piston is used to pack and unpack the chromatography bed substantially to avoid voids therein, and to maintain bed compression during use. This maintenance of the compression effectively and substantially prevents the formation of voids in the bed, which increases the efficiency of the procedure. The column can be packed with any packing material, including small particle size (e.g., about 10 µm) media. In this way, very high plate numbers are generated. The bed length can be adjusted by controlling the amount of packing material used to prepare the column.

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