Process for the isolation and purification of mevinolin

C - Chemistry – Metallurgy – 12 – P

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C12P 17/06 (2006.01) C07D 309/30 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2127381

In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carryingout the dissolving at a pH between about 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.

Dans un procédé de préparation de la mévinoline par fermentation de biomasse dans un liquide de fermentation, qui comprend la dissolution de la mévinoline provenant de la biomasse dans le liquide de fermentation, la séparation de la biomasse du liquide de fermentation pour obtenir un liquide de fermentation séparé, la séparation de la mévinoline du liquide de fermentation séparé et la récupération du produit final, l'amélioration consistant à réaliser la dissolution à un pH se situant entre environ 7,5 et environ 10 et la séparation de la mévinoline, à un pH se situant entre environ 4,5 et environ 1.

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