Process for the manufacture of tris (2-hydroxyethyl)...

Details Process for the manufacture of tris (2-hydroxyethyl)... Process for the manufacture of tris (2-hydroxyethyl)...

C - Chemistry, Metallurgy

07

C

260/514.4, 260/6

C07C 59/70 (2006.01)

Patent

CA 1036618

ABSTRACT OF THE DISCLOSURE Tris(2-hydroxyethyl)ammonium-ortho-cresoxyacetate, has the following formula: [o-CH3C6H4OCH2COO] - [NH(CH2CH2OH)3]+, useful for treating malignant neoplasms. A process for the manufacture of said substance, in accordance with the invention, comprises reacting triethanolamine with o-cresoxy- acetic acid at a temperature of up to 100°C and subsequently recovering the desired product. The invention also includes medicinal preparation for treating malignant neoplasms, which comprises an active principle, tris(2-hydroxyethyl)ammonium- ortho-cresoxyacetate of the following formula: [o-CH3C6H4OCH2COO] - [NH(CH2CH2OH)3]+, or said active principle combined with a pharmaceutical solvent for injections or a pharmaceutical filler for tablets.

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