C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/266.3
C07D 401/10 (2006.01) C07D 215/58 (2006.01) C07F 5/02 (2006.01)
Patent
CA 1294621
A B S T R A C T The present invention relates to a process for the preparation of compounds of the general Formula I Image /I/ and pharmaceutically acceptable salts thereof (wherein R stands for piperazinyl or 4-methyl-piperazinyl) which comprises reacting a compound of the general Formula II Image /II/ (wherein R1 and R2 stand for halogen; an aliphatic acyl- oxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or an aromatic acyloxy group comprising 7-11 carbon atoms) with a piperazine of the general Formula III Image /III/ (wherein R3 represents hydrogen or methyl) or a salt thereof, hydrolysing the compound of the general for- mula IV /IV/ Image thus obtained (wherein R, R1 and R2 are as stated above) without or after hydrolysis and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the general Formula I are known antibacterial agents. The advantage of the process of the present inven- tion is that it enables the preparation of the compounds of the general formula I in a simple manner, with high yields and in a short reaction time.
524727
Balogh Maria
Hermecz Istvan
Horvath Agnes
Kereszturi Geza
Kovacs Gabor
Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt.
Fetherstonhaugh & Co.
LandOfFree
Process for the preparation of 1-methylamino-... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of 1-methylamino-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 1-methylamino-... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1327755