Process for the preparation of 7-amino syn 3,5-dihydroxy...

C - Chemistry – Metallurgy – 07 – C

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C07C 227/32 (2006.01) C07C 69/67 (2006.01) C07C 69/716 (2006.01) C07C 69/732 (2006.01) C07C 69/738 (2006.01) C07C 229/22 (2006.01) C07C 235/04 (2006.01) C07C 235/06 (2006.01) C07C 235/74 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2453211

The invention relates to synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to synthesis methods of the intermediate of formula (VI) wherein Ra' and Rc' are each independently of the other hydrogen or hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy- protecting group, which methods are carried out by conversion of the intermediate of formula (XVI) wherein Ra' and Rc' are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further intermediates and methods for their preparation.

La présente invention a trait à de nouveaux procédés de synthèse pour la préparation d'intermédiaires aptes à la préparation de dérivés de statine, notamment de nouveaux procédés de synthèse de formule (VI), dans laquelle: R¿a?' et R¿c?' sont chacun indépendamment l'un de l'autre hydrogène ou un groupe hydroxy protecteur ou ensemble forment un groupe hydroxy protecteur de liaison, et R¿b? est un groupe carboxy protecteur, lesquels procédés sont mis en oeuvre par la conversion de l'intermédiaire de formule XVI, dans laquelle: R¿a?' et R¿c?' sont indépendamment l'un de l'autre hydrogène ou un groupe hydroxy protecteur, R* et R** sont indépendamment l'un de l'autre hydrogène ou un groupe amide protecteur, et R¿b? est un groupe carboxy protecteur: lesquels procédés permettent de réaliser de nouveaux intermédiaires et procédés pour leur préparation.

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