Process for the preparation of 7-substituted-hept-6-enoic...

Details Process for the preparation of 7-substituted-hept-6-enoic... Process for the preparation of 7-substituted-hept-6-enoic...

C - Chemistry, Metallurgy

07

C

260/478, 260/319

C07C 59/74 (2006.01) C07C 51/367 (2006.01) C07C 59/48 (2006.01) C07C 223/00 (2006.01) C07C 223/02 (2006.01) C07D 209/12 (2006.01) C07D 209/24 (2006.01) C07D 233/54 (2006.01)

Patent

CA 2000553

A novel process for the preparation compounds of formula I (See formula I) wherein X is -CH2CH2- or -CH=CH-; R is an ester group inert to the reaction conditions; and R is an organic radical having groups which are inert under reducing conditions, by stereoselective reduction of a corresponding compound of formula II (See formula II) wherein R, R2 and X are as defined above and one of Z1 and Z2 is oxygen and the other is hydroxy and hydrogen, is disclosed. The compounds of formula I are pharmaceuticals, especially anti- atherosclerotic, antihyperlipidemic and antihypercholesterolemic agents.

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