Process for the preparation of a compound having anti- ulcer...

Details Process for the preparation of a compound having anti- ulcer... Process for the preparation of a compound having anti- ulcer...

C - Chemistry, Metallurgy

07

D

260/353.3

C07D 407/12 (2006.01) A61K 31/34 (2006.01) A61K 31/36 (2006.01) C07D 307/00 (2006.01) C07D 307/52 (2006.01) C07D 317/00 (2006.01) C07D 317/58 (2006.01) C07D 407/00 (2006.01) C07D 407/02 (2006.01)

Patent

CA 1227492

- 1 - "PROCESS FOR THE PREPARATION OF A COMPOUND HAVING ANTI- ULCER ACTIVITY" Abstract of the disclosure The invention refers to processes for the preparation of N-/?/?/?/?-(dimethylamino)methyl?-2-furanyl?methyl?thi?- ethyl?-N'-(3,4-methylenedioxybenzyl)-2-nitro-1,1-ethenedia- mina of formula (I) (I) Image mainly characterized by the reaction of 2-(dimethylaminome- thyl)-5-(R-methyl)furan wherein R represents hydroxy, ha- logen, dimethylamino or trimethylammonium iodide with 1- nitro-2-(3,4-methylenedioxybenzyl)-2-(2-mercaptoetnyl)ethe- nediamine; or with N-(2-mercaptoethyl)-N'-(3,4-methylenedio xybenzyl)urea or thiourea and subsequent reaction of the ob tained intermediate with nitromethane; or also by condensa tion of 2-(dimethylaminomethyl)-5-(2-hydroxy)ethylthiomethyl- furan with 2-amino-2-(3,4-methylenedioxybenzylamino)-1-ni- troethene.

475947

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