Process for the preparation of homonojirimycin derivatives

C - Chemistry – Metallurgy – 07 – D

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260/506, 260/292

C07D 211/60 (2006.01) C07D 211/46 (2006.01) C07H 15/26 (2006.01)

Patent

CA 1314894

ABSTRACT OF THE DISCLOSURE A procedure for the mild conversion of a carbonitrile to the corresponding carboxylic acid by first using tri- fluoroacetic acid in the presence of a catalytic amount of mercuric ion followed by oxidative hydrolysis with dini- trogen tetroxide is described herein. The use of this procedure in the preparation of 1,3,4,5-tetra-O-benzoyl- 2,6-dideoxy-2,6-imino-D-glycero-L-gulo-heptitol hydrochloride is also described here. M01356

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