Process for the preparation of lyophilized, adsorbed...

Details Process for the preparation of lyophilized, adsorbed... Process for the preparation of lyophilized, adsorbed...

A - Human Necessities

61

K

167/129

A61K 39/02 (2006.01) A61K 9/00 (2006.01) A61K 39/05 (2006.01) A61K 39/08 (2006.01) A61K 39/10 (2006.01) A61K 39/116 (2006.01)

Patent

CA 1234048

ABSTRACT OF THE DISCLOSURE The invention relates to the preparation of iyophll- ized, adsorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to 15 doses/3 ml are adsorbed at a pH value of 3 to 6 to an insoluble carrier concentrated in the same way as the antigens, then the pH of the mixture is adjusted to a value of 5 to 6 and iyophllized together with a protective material commonly used in iyophllizing processes. Before administration the iyophllized vaccine is diluted to the concentration required by a physiological saline buffered to a pH value of 6.8 to 7 by a phosphate solution.

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