Process for the preparation of n-amino substituted...

Details Process for the preparation of n-amino substituted... Process for the preparation of n-amino substituted...

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01)

Patent

CA 2540867

An improved process for the preparation of N-amino nitrogen heterocyclic compounds is disclosed and claimed. In an ambodiment of this invention, a compound of the formula (VI) is prepared starting from the corresponding indole derivative by way of N-amination and subsequently forming an hydrazone by the reaction with a keto compound in a single step. Further reduction of the hydrazone and subsequent coupling with a pyridine compound affords the compound of formula VI or a suitable salt thereof.

L'invention décrit un procédé amélioré de préparation de composés hétérocycliques d'azote N-amino. Dans un mode de réalisation de l'invention, un composé de formule (VI) est obtenu à partir du dérivé d'indole correspondant par N-amination puis par formation d'un hydrazone par réaction avec un composé cétone en une seule étape. La réduction de l'hydrazone et le couplage subséquent avec un composé pyridine permettent d'obtenir le composé de formule VI ou un sel approprié correspondant.

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