Process for the preparation of substituted 3,5-...

C - Chemistry – Metallurgy – 07 – C

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C07C 211/52 (2006.01) C07C 201/12 (2006.01) C07C 205/12 (2006.01) C07C 209/36 (2006.01) C07C 265/12 (2006.01)

Patent

CA 1304392

Process for the preparation of substituted 3,5-di- chloro-2,4-difluoro-benzenes A b s t r a c t Substituted 3,5-dichloro-2,4-difluoro-benzenes of the formula Image (1), in which R represents nitro, amino (including the corres- ponding ammonium salts) or isocyanato, which can be prepared from 2,3,4,5-tetrachloro-nitrobenzene by means of the reaction, carried out initially, with alk- ali metal fluorides at elevated temperature in a polar, aprotic solvent, starting from a crude 2,3,4,5-tetrachloro- nitrobenzene containing 2,3,5,6-tetrachloro-nitrobenzene and/or 2,3,4,6-tetrachloro-nitrobenzene, and substituted 3,5-dichloro-2,4-difluoro-benzene being isolated from the reaction mixture at the nitro stage or, after reduction of the nitro group, at the amino stage or, after reduction and phosgenation of the amino group, at the isocyanate stage. Le A 24 613-US

553875

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