Process for the production of 2-substituted...

Details Process for the production of 2-substituted... Process for the production of 2-substituted...

C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) C07D 239/545 (2006.01) C07D 239/60 (2006.01)

Patent

CA 2083790

A process is disclosed for the production of 2-substituted 4,6-dialkoxypyrimidines of the formula: (see formula I) wherein R1 and R2 each independently represent a lower alkyl group, and R3 represents an R4-O-, R4-S- or Image group, in which R4 is lower alkyl and R5 is hydrogen, lower alkyl or phenyl. The process includes cyclizing a cyanimidate of the general formula: (see formula II) with a hydrogen halide to form a halopyrimidine derivative of the general formula: (see formula III) The latter is then converted either with a compound of the formula: M-R3 (IV) or with an alkyl amine of the general formula: (see formula V) into the end product of general formula I.

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