Process for the production of citalopram

Details Process for the production of citalopram Process for the production of citalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) A61K 31/34 (2006.01) C07D 209/44 (2006.01)

Patent

CA 2444940

The invention relates to a process for the manufacture of salts of citalopram in high purity. By the careful selection of solvents and the careful manipulation of the pH value, citalopram salts may be isolated in the absence of 5-chlorocitalopram, 5-bromocitalo-pram, desmethyl-citalopram and 5- carobxyamide citalopram.

L'invention concerne un procédé de fabrication de sels de citalopram de pureté élevée. Grâce à une sélection dosée de solvants et une manipulation soigneuse de la valeur de pH, les sels de citalopram peuvent être isolés en absence de 5-chlorocitalopram, 5-bromocitalo-pram, desméthyl-citalopram et 5-carboxyamide citalopram.

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