Process for the stereoselective enzymatic hydrolysis of...

C - Chemistry – Metallurgy – 12 – P

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Details

C12P 7/40 (2006.01) C07C 205/51 (2006.01) C07C 229/08 (2006.01) C12P 7/62 (2006.01) C12P 13/00 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2724828

The present invention relates to processes for the preparation of 5-methyl-3- nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3- nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5- methylhexanoic acid. (S)-5-Methyl-3- nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hex- anoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.

La présente invention porte sur des procédés de préparation d'un ester d'acide 5-méthyl-3-nitrométhyl-hexanoïque et de ses sels. L'invention porte également sur des procédés de préparation d'un sel d'acide 5-méthyl-3-nitrométhyl-hexanoïque et sur un procédé de préparation de l'acide 3-(aminométhyl)-5-méthylhexanoïque. L'invention porte sur l'acide (S)-5-méthyl-3-nitrométhyl-hexanoïque ou sur l'acide (R)-5-méthyl-3-nitrométhyl-hexanoïque sous forme énantio-enrichie ou sous forme énantiopure ainsi que sur les sels de ceux-ci, sur un ester d'acide (S)-5-méthyl-3-nitrométhyl-hexanoïque ou sur un ester d'acide (R)-5-méthyl-3-nitrométhyl-hexanoïque sous forme énantio-enrichie ou sous forme énantiopure, et sur un composé, à savoir le composé de Formule (XIII), sous forme racémique, sous forme énantio-enrichie ou sous forme énantiopure.

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