Process of producing a pyrazine derivative

Details Process of producing a pyrazine derivative Process of producing a pyrazine derivative

C - Chemistry, Metallurgy

07

D

260/246, 260/266

C07D 403/12 (2006.01) C07D 241/18 (2006.01) C07D 241/24 (2006.01) C07D 295/14 (2006.01)

Patent

CA 1050540

A B S T R A C T OF THE DISCLOSURE A process of producing a pyrazine derivative represented by the formula Image wherein R1 and R2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkyl- thio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R3 represents a lower alkoxy group; R4, R5, and R6, which may be the same of different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R4 and A, said R5 and A, said R4 and R5, or said R5 and R6 may form a 5-membered or 6-membered nitrogen-containing hetero- cyclic ring which may further contain a hetero-atom together with nitrogen atom and the pharmacologically acceptable non-toxic salts thereof. The compound of this invention has a strong and selective antiemetic activity and an effect of stimulating the gastric motility.

217443

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